University of Zambia Medical Library



ZAMBIA HEALTH INFORMATION DIGEST

Volume 5 Number 1 Jan-Mar 1998

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[ZHID Table of Contents]

EDITORIAL BOARD:
Dr. J.C. L. Mwansa, Microbiologist: University Teaching Hospital
Dr. Andrew L.Mbewe, Consultant Paediatrician: Kitwe Central Hospital
Dr. Oliver Bowa, Surgical Anatomist: University of Zambia Surgery Department
Ms. Regina Shakakata, Health Information & Promotions Officer: World Health Organisation-Zambia
Dr. Katele Kalumba: Minister of Health, Zambia
Dr. Mannasseh Phiri, Chief Medical Officer: Company Clinic, Kitwe
Mrs. Norah Mumba, Medical Librarian (Ag): University of Zambia Medical Library

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The Zambia Health Information Digest is produced to provide current information to health workers who have little access to current health related publications and information.

SOURCE:
The abstracts of journal articles published in this quarterly Digest are obtained from the MEDLINE databases provided by the Dreyfus Health Foundation of New York. Abstracts are also selected from a database of Zambian health articles, which is continually being compiled at the UNZA Medical Library. Readers are encouraged to send in their work for inclusion in this Zambian health information database.
Computer equipment has been supplied through a grant from the IBM Corporation. Subjects that are prominently reflected on the Medical Library's MEDLINE search requests and information on prevalent health conditions seen in Zambia are published. Other health related subjects are also included.
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Production costs are supported by The Dreyfus Health Foundation of New York. Full articles on unsafe abortion are provided by courtesy of Commonwealth Regional Health Community Secretariat for East, Central and Southern Africa (CRHCS), who have also contributed generously to the expansion of the Digest. We encourage readers to submit requests for articles highlighted in the Digest.

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TABLE OF CONTENTS:


EDITORIAL:

We have decided to tackle the topic nutrition, which has both social and medical impact on communities especially in the Third World. Kwashiorkor is a common paediatric problem in most parts of Africa. It has been established that efforts need to focus not only on case management protocols but also and especially on how to actually improve practice in this regard.

In situations of armed conflict, nutrition becomes more topical. In 1995, war is reported to have been directly or indirectly affecting 550 million people in 35 countries. The risk for malnutrition and deficiencies is made worse by the loss of means of production, of food stocks, of commerce and by banditism as military operations target water plants and health facilities as means of deliberately hurting civilians.

Malnutrition has other effects on such as the interactions identified between protein-energy malnutrition and parasite infections in Central Africa. HIV-related diarrhoea and resultant wasting also has nutritional implications. There have been some explorations to establish whether or not there is some link between prolonged breastfeeding and malnutrition.

Nutrition is of concern not only with regard to children but also to adults and particularly the elderly.


NUTRITION (CURRENT ABSTRACTS OF JOURNAL ARTICLES -- MEDLINE)

Childhood protein-energy malnutrition and parasite infections

A clear understanding of protein-energy malnutrition (PEM), parasite infection and their interactions is essential in formulating health and development policies. We studied the prevalence of PEM indicators and the prevalence and/or intensity of infection in 558 Zairian children aged 4 months to 10 years. Multivariate analyses were used to estimate relationships between PEM indicators and parasitic infection. Stunting was found in 40.3% of children, wasting in 4.9% and kwashiorkor in 5.1%. The risk of stunting was significantly higher in children with Ascaris lumbricoides. The risk of wasting was higher in children with A. lumbricoides or Trichuris trichiura, whereas the risk of kwashiorkor was high with T. trichiura but very reduced in those with A. lumbricoides. Plasmodium infection was not related to nutritional indicators. These relationships highlight important interactions, both synergistic and antagonistic, between nutrition and parasites in central Africa.
Tshikuka JG. Gray-Donald K. Scott M. Olela KN. Relationship of childhood protein-energy malnutrition and parasite infections in an urban African setting. Tropical Medicine & International Health. 2(4):374-82, 1997 Apr.

Case management of kwashiorkor


Brewster DR. Manary MJ. Graham SM. Case management of kwashiorkor: an intervention project at seven nutrition rehabilitation centres in Malawi. European Journal of Clinical Nutrition. 51(3):139-47, 1997 Mar.

Efficacy of outreach nutrition rehabilitation centres


Perra A. Costello AM. Efficacy of outreach nutrition rehabilitation centres in reducing mortality and improving nutritional outcome of severely malnourished children in Guinea Bissau. European Journal of Clinical Nutrition. 49(5):353-9, 1995 May.

Nutritional assessments, food security and famine

The widely held view that malnutrition is a late indicator of famine is challenged on the basis of evidence that people often deliberately reduce their food intake as an early response to inadequate food security. This broadens the possible interventions in response to high malnutrition rates to include measures to support livelihoods under threat of collapse. In the late stages of famine, social disruption and distress migration often result in a degraded health environment which may raise the threshold of nutritional status associated with an increased mortality risk. It is important to assess the underlying causes of malnutrition and the associated health risks.

At present, the main objective of nutrition surveys is usually to obtain a reliable estimate of the prevalence of malnutrition among children under five years of age, with little analysis of the underlying causes of malnutrition. Experience from the 1984-85 famine in Darfur led to the development of an alternative approach to nutritional assessment which could be applicable elsewhere in Africa. The combination of quantitative and qualitative methods was particularly valuable as a means of gaining a wider and deeper understanding of the nature of the nutritional situation.
Young H. Jaspars S. Nutritional assessments, food security and famine. Disasters. 19(1):26-36, 1995 Mar.

Mortality of severely malnourished children


Prudhon C. Golden MH. Briend A. Mary JY. A model to standardise mortality of severely malnourished children using nutritional status on admission to therapeutic feeding centres. European Journal of Clinical Nutrition. 51(11):771-7, 1997 Nov.

Armed conflicts, health & health services in Africa

Because of war, between the 1980s and early '90s Africa suffered about 5 million excess deaths and economic losses estimated at US $13 billion per year. In 1995, war was directly or indirectly affecting 550 million people in 35 countries. Besides violent deaths, injuries and disabilities, displacements of population increase the risk for acute respiratory infections, diarrhoeas, epidemics and parasitic disease. The risk for malnutrition and deficiencies is made worse by the loss of means of production, of food stocks, of commerce and by banditism.

Military operations target water plants and health facilities as means of deliberately hurting civilians. Economic crisis curtails the budgets of the social sectors and, together with social distress, undermines national capacities. The delivery of health care is hampered right when hazards and vulnerabilities increase, with general greater risk of illness and death. With the cessation of hostilities, the need for curative and preventative health activities increases and is a matter of emergency, as equitable access to services is important for peace. Repatriation of refugees, demobilization of soldiers and demining require special health activities.

War leaves behind new hazards and vulnerabilities such as landmines, wide availability of weapons, artificial concentrations of population, loss of national capacities and psychological disorders. All this interacts tragically with Africa's wider epidemiological realities of poverty, food insecurity, proneness to natural disasters and endemic diseases.
Loretti A. Armed conflicts, health and health services in Africa. An epidemiological framework of reference. Medicine, Conflict & Survival. 13(3):219-28, 1997 Jul-Sep.

Childhood protein-energy malnutrition & parasite infections

A clear understanding of protein-energy malnutrition (PEM), parasite infection and their interactions is essential in formulating health and development policies. We studied the prevalence of PEM indicators and the prevalence and/or intensity of infection in 558 Zairian children aged 4 months to 10 years. Multivariate analyses were used to estimate relationships between PEM indicators and parasitic infection.

Stunting was found in 40.3% of children, wasting in 4.9% and kwashiorkor in 5.1%. The risk of stunting was significantly higher in children with Ascaris lumbricoides. The risk of wasting was higher in children with A. lumbricoides or Trichuris trichiura, whereas the risk of kwashiorkor was high with T. trichiura but very reduced in those with A. lumbricoides. Plasmodium infection was not related to nutritional indicators. These relationships highlight important interactions, both synergistic and antagonistic, between nutrition and parasites in central Africa.
Tshikuka JG. Gray-Donald K. Scott M. Olela KN. Relationship of childhood protein-energy malnutrition and parasite infections in an urban African setting. Tropical Medicine & International Health. 2(4):374-82, 1997 Apr.

Epidemiological aspects of diabetes

Diabetes is a worldwide public health problem made more acute in Africa by low socio-economic standards. Cases with an unusual clinical course are frequent and probably related to tropical diabetes, a syndrome that has not yet been precisely defined.

This study reports the results of a prospective study carried out in Cameroon on 550 diabetic patients attending the Yaounde Central Hospital who were followed between December 1990 and July 1994. They were classified according to WHO criteria into 136 insulin-dependent diabetes mellitus (IDDM) (24.7%), 405 non-insulin- dependent diabetes mellitus (NIDDM) (73.7%) and 9 diabetes secondary to other diseases (1.6%). No cases of malnutrition-related diabetes mellitus (MRDM) were found, but 18 subjects were considered to have so-called "African diabetes".

Investigation of the cohort showed epidemiological and clinical features markedly different from those of Caucasian diabetic subjects. The age of onset in IDDM occurred in all age groups, with a mean (+/- SD) close to that of NIDDM (40.9 +/- 4.8 years vs 49 +/- 10.9; P <0.001). A clear male preponderance was found (M/F sex ratio = 1.63), as it has been reported in most studies from sub-Saharan Africa, in contrast with the slight female predominance noted in the Sahel and Saharan countries. An increased prevalence of young and non-obese NIDDM was also found. Seventy-nine NIDDM cases (19.5%) were detected in individuals under 40 years of age, including 31 with normal weight. Many atypical features were noted: IDDM in obese patients, NIDDM in ketotic subjects and patients with varying insulin requirements, all of which led to difficulties in classifying many diabetic patients according to current practices. All these uncommon features are concordant with the nature of tropical diabetes, including not only MRDM but also African diabetes which occurs in individuals older than MRDM patients who show no signs of malnutrition. Thus, tropical diabetes is apparently a syndrome with aetiological heterogeneity which requires further definition through clinical, genetic and immunological studies.
Ducorps M. Ndong W. Jupkwo B. Belmejdoub G. Poirier JM. Mayaudon H. Bauduceau B. Epidemiological aspects of diabetes in Cameroon: what is the role of tropical diabetes? Diabetes & Metabolism. 23(1):61-7,1997 Feb.

Public health aspects of emergencies & refugee situations

Populations affected by armed conflict have experienced severe public health consequences mediated by population displacement, food scarcity, and the collapse of basic health services, giving rise to the term complex humanitarian emergencies. These public health effects have been most severe in underdeveloped countries in Africa, Asia, and Latin America. Refugees and internally displaced persons have experienced high mortality rates during the period immediately following their migration.

In Africa, crude mortality rates have been as high as 80 times baseline rates. The most common causes of death have been diarrheal diseases, measles, acute respiratory infections, and malaria. High prevalences of acute malnutrition have contributed to high case fatality rates.

In conflict-affected European countries, such as the former Yugoslavia, Georgia, Azerbaijan, and Chechnya, war-related injuries have been the most common cause of death among civilian populations; however, increased incidence of communicable diseases, neonatal health problems, and nutritional deficiencies (especially among the elderly) have been documented. The most effective measures to prevent mortality and morbidity in complex emergencies include protection from violence; the provision of adequate food rations, clean water and sanitation; diarrheal disease control; measles immunization; maternal and child health care, including the case management of common endemic communicable diseases; and selective feeding programs, when indicated.
Toole MJ. Waldman RJ. The public health aspects of complex emergencies and refugee situations. Annual Review of Public Health. 18:283-312, 1997.

Presentation & outcome of HIV-1 infection in hospitalised infants

There is limited information on HIV infection in children in West Africa. This prospective case series study was done to determine the size of the problem and the feasibility of selective screening for infection based on clinical presentation. It involved infants and other children admitted to the Children's Emergency Ward and Paediatric Medical Ward of the University of Maiduguri Teaching Hospital, Nigeria, from the beginning of September 1992 to the end of September 1994.

Clinical evaluation followed by serologic tests (ELISA and Western blot techniques) was undertaken. Descriptive study; frequencies were compared using chi 2 test for Fisher's exact test as appropriate. One hundred and ninety nine (10.9%) of 1,822 admissions were screened. One hundred and fifty eight (79.4%) were ELISA negative and 17 (8.6%) ELISA and WB positive; a further 10 (5%) were ELISA positive but WB indeterminate and 14 (7%) were ELISA positive but WB negative in 12 or untested in two. All the infections were HIV-1. Sixteen (39%) patients (nine WB positive, three WB indeterminate and four ELISA positive only) are dead, 14 from HIV-related illnesses, two (4.9]) are alive and 23 (56.1%) lost to follow up; 11 of the HIV-related deaths involved infants.

Presence of persistent diarrhoea, prolonged fever, oral thrush, hepatosplenomegaly, diagnosis of tuberculosis and severe malnutrition with gastroentereritis, and multiple (> 3) diagnosis on admission were significantly (p < 0.05) associated with WB confirmed HIV-1 seropositivity and could serve as indicators for selective screening. HIV-1 infection in hospitalised infants and children has become an important problem in Nigeria, presentation in infancy is associated with a high case fatality rate, and the practice of selective screening based on clinical presentation would appear to be feasible.
Akpede GO. Ambe JP. Rabasa AI. Akuhwa TR. Ajayi BB. Akoma MA. Bukbuk DN. Harry TO. Presentation and outcome of HIV-1 infection in hospitalised infants and other children in north-eastern Nigeria. East African Medical Journal. 74(1):21-7, 1997 Jan.

Moderate to mild malnutrition in African children

In all Third World populations, among preschool and schoolchildren, low weight- and height-for-age, i.e. below the 5th centile of US NCHS reference standards, are common, affecting 10-50%. Orthodoxly, shortfalls are attributed largely to insufficiency of food. In an attempt to throw more light on the situation regarding African schoolchildren, studies have been made on series of pupils, aged 10-12 years, at three rural schools in North West Province, South Africa.

Of 396 pupils, 126 (31.8%) were below, and 270 (68.2%) above the 5th centile. Enquiries were made on each pupil's diet and meal pattern, their class position and games aptitude, and, regarding home characteristics, their family size, Parent(s) working, and the latter's interest in education. With minor exceptions, no significant differences in odds ratios were found between respective groups below and above the 5th centile. Evidently, there are multiple influencing factors. Hence, among children of school-age, there must be caution against overblaming undernutrition, and of overrating the health disadvantages from mild to moderate malnutrition. For definition clarification, long-term observations are necessary.
Walker AR. Walker BF. Moderate to mild malnutrition in African children of 10-12 years: roles of dietary and non-dietary factors. International Journal of Food Sciences & Nutrition. 48(2):95-101, 1997 Mar.

Determinant of wasting in Zambians with HIV-related diarrhoea

Wasting in African AIDS patients is severe, and its aetiology is probably multifactorial: persistent diarrhoea, poverty and tuberculosis may all contribute. We report a cross-sectional study of body composition measured anthropometrically in 75 adult patients with HIV-related persistent diarrhoea in Lusaka, and its relationship to gastrointestinal infection and systemic immune activation assessed using serum neopterin and soluble tumour necrosis factor receptor (sTNF-R55) concentrations. Patients as a group were generally severely wasted (mean body mass index (BMI) 15.8 kg/m2, range 11-22), but the severity of wasting was related neither to oesophageal candidiasis nor to intestinal infection.

In men but not women, all measures of nutritional status were negatively related to serum sTNF-R55 concentration (fat-free mass in men, r = -0.64; 95% CI: -0.80, -0.41; p < 0.0001). Some wasted patients had cutaneous features of malnutrition, again associated with higher sTNF55 concentrations, and two had peripheral oedema. The diarrhoea-wasting syndrome in this part of Africa seems to be associated with evidence of high cytokine activity in men, rather than oesophageal candidiasis or any particular intestinal opportunistic infection. This immune activation requires further investigation in the context of the sex difference we have observed.
Kelly P. Summerbell C. Ngwenya B. Mandanda B. Hosp M. Fuchs D. Wachter H. Luo NP. Pobee JO. Farthing MJ. Systemic immune activation as a potential determinant of wasting in Zambians with HIV-related diarrhoea. QJM. 89(11):831-7, 1996 Nov.

The reality of despair: AIDS in Malawi

While completing a recent medical elective in the Central African country of Malawi, medical student Dale Needham learned firsthand that HIV/AIDS represents a true pandemic in Africa. By the end of 1993, Malawi had the continent's highest per capita number of cumulative reported AIDS cases. Although Canadian physicians have had their own struggles helping patients with HIV/AIDS, many more battles are being fought in countries like Malawi, where financial resources are limited. In Africa, HIV-positive people of all ages suffer incredibly from diseases such as protein energy malnutrition, tuberculosis and cryptococcal meningitis. Primary health care programs, education in the primary schools and community awareness and support are partial answers to the pandemic.
Needham D. The reality of despair: AIDS in Malawi. CMAJ. 155(1):91-2, 1996 Jul 1.

Is prolonged breastfeeding associated with malnutrition?


Caulfield LE. Bentley ME. Ahmed S. Is prolonged breastfeeding associated with malnutrition? Evidence from nineteen demographic and health surveys. International Journal of Epidemiology. 25(4):693-703, 1996 Aug.

Bacteraemia in malnourished rural African children

During a 5-month study period, 323 of 863 (37.5%) children below 5 years of age admitted to Shongwe Mission Hospital in rural South Africa were malnourished, two-thirds severely so. The incidence of bacteraemia in malnourished children was 9.6%, 11.8% in those severely malnourished and 5.8% in nutritional dwarfs. The predominant organisms retrieved were Gram-negative enteric bacilli (48.5%). Amongst the severely malnourished, who empirically receive intravenous ampicillin and gentamicin, 95.8% of all isolates were sensitive to this antibiotic combination. The case fatality rate of severely malnourished bacteraemic children was 20.8%. In malnutrition categories overall, the case fatality rate for bacteraemic children (22.6%) was significantly greater than in those without bacteraemia (9.3%). In hospitals with limited resources, full identification of bacteria may not be necessary, provided that regular surveillance for emerging resistance is conducted.
Reed RP. Wegerhoff FO. Rothberg AD. Bacteraemia in malnourished rural African children. Annals of Tropical Paediatrics. 16(1):61-8, 1996 Mar.

Adult malnutrition

The recent recognition of the problem of adult malnutrition requires methods for specifying the severity of undernutrition. The measurement of mid upper arm circumference (MUAC) can now be used as a screening method for underweight (normally assessed from the BMI) or as an additional criterion with the BMI to identify the preferential loss of peripheral tissue stores of fat and protein.

By analysing and extrapolating anthropometric data from nine detailed adult surveys from Asia, Africa and the Pacific a series of MUAC cut-off points have now been identified to allow the screening of individual adults under extreme conditions, e.g. during famine. Grade 4 malnutrition is now specified for those with a MUAC < 200 mm for men and < 190 mm for women since these MUAC values correspond to the loss of fat stores at BMI of < 13. Food supplementation is clearly needed in these individuals. Extreme wasting (grade 5 malnutrition) corresponds to MUAC values of < 170 and < 160 mm for men and women respectively. These adults have extremely low BMI, i.e. about 10, have lost most, if not all, of their protein stores and are at a high risk of imminent death. These individuals will need immediate special feeding regimens to ensure their survival. The sex-specific MUAC values corresponding to BMI of 16, 13 and 10 can now therefore be used for rapid screening and the choice of remedial action.
Ferro-Luzzi A. James WP. Adult malnutrition: simple assessment techniques for use in emergencies. British Journal of Nutrition. 75(1):3-10, 1996 Jan.

Urinary ioxide excretion in relation to other nutritional parameters


Akanji AO. Mainasara AS. Akinlade KS. Urinary iodine excretion in mothers and their breast-fed children in relation to other childhood nutritional parameters. European Journal of Clinical Nutrition. 50(3):187-91, 1996 Mar.

AIDS & malnutrition in rural Ivory Coast

To assess the role of human immunodeficiency virus (HIV) infection in malnutrition in African children, clinical examination and serologic tests were performed in 183 undernourished children at the Protestant Hospital of Dabou which is located in a semi-urban area of Cote d'Ivoire.

Malnutrition was noted in 18% of children admitted to the Pediatric Department including 70.5% with marasmus. Serologic tests were positive for HIV in 46 of the 183 children, i.e. 25.1%. The type of malnutrition was not significantly different in seropositive children. Breast feeding was more common in the seropositive than seronegative group (59% vs 39%) (p<0.05). Follow-up at the nutrition center was poorer quality and less effective in seropositive than seronegative children. The results of this study demonstrate the important role of HIV infection first as a cause and second as an impediment for management of malnutrition in Black Africa.
Mutombo T. Keusse J. Sangare A. [AIDS and malnutrition in a pediatric semi-rural milieu of Ivory Coast]. Medecine Tropicale. 55(4):357-9, 1995.

Physical activity, illness and nutritional status


Alemu T. Lindtjorn B. Physical activity, illness and nutritional status among adults in a rural Ethiopian community. International Journal of Epidemiology. 24(5):977-83, 1995 Oct.

Noma: a neglected scourge of children in sub-Saharan Africa

Poverty is the single most important risk indicator for noma (cancrumoris), a severe gangrene of the soft and hard tissues of the mouth, face, and neighbouring areas. The risk factors associated with an increasedprobability of noma developing include the following: malnutrition, poor oral hygiene, and a state of debilitation resulting from human immunodeficiency virus (HIV) infection, measles, and other childhood diseases prevalent in the tropics.

There are many similarities between noma and necrobacillosis of the body surface of wallabies (Macropus reforgriseus), and it is proposed that noma results from oral contamination by a heavy load of Bacteroidaceae (particularly Fusobacterium necrophorum) and a consortium of other microorganisms. These opportunistic pathogens invade oral tissues whose defences are weakened by malnutrition, acute necrotizing gingivitis, debilitating conditions, trauma, and other oral mucosal ulcers.

The current escalation in the incidence of noma in Africa can be attributed to the worsening economic crisis in the region, which has adversely affected the health and well-being of children through deteriorating sanitation, declining nutritional status and the associated immunosuppression, and increased exposure to infectious diseases. Prevention of noma in Africa will require measures that address these problems, and most importantly, eliminate faecal contamination of foods and water supplies. [References: 47]
Enwonwu CO. Noma: a neglected scourge of children in sub-Saharan Africa. [Review] Bulletin of the World Health Organization. 73(4):541-5, 1995.

Food and the gut

A.R.P. Walker pioneered the research into the association between food, gut function and disease patterns in southern Africa. His attention to ways in which dietary differences can explain geographical differences in disease patterns has led to the realisation that civilisation and modern food technology can exert a strong influence on dietary practices, gut function and disease tendencies.

Recognition that South African blacks have a very low incidence of colonic problems such as diverticulitis, adenomatous polyps and carcinoma drew attention to the possibility that the traditional African diet, with a high fibre content, may maintain colonic health and prevent disease in old age. This review explores some of the mechanisms that may account for these differences and also examines ways in which malnutrition alters gut function. To quote Walker's conclusions: 'There is a need, indeed a duty, for writers on nutrition to devote a portion of their space to the nutritional lessons to be learned from the past, from war-time experiences and from present day Third-World populations.'
O'Keefe SJ. A.R.P. Walker Lecture. Food and the gut. [Review] South African Medical Journal. 85(4):261-8, 1995 Apr.

Nutritional assessments, food security & famine

The widely held view that malnutrition is a late indicator of famine is challenged on the basis of evidence that people often deliberately reduce their food intake as an early response to inadequate food security. This broadens the possible interventions in response to high malnutrition rates to include measures to support livelihoods under threat of collapse. In the late stages of famine, social disruption and distress migration often result in a degraded health environment which may raise the threshold of nutritional status associated with an increased mortality risk.

It is important to assess the underlying causes of malnutrition and the associated health risks. At present, the main objective of nutrition surveys is usually to obtain a reliable estimate of the prevalence of malnutrition among children under five years of age, with little analysis of the underlying causes of malnutrition. Experience from the 1984-85 famine in Darfur led to the development of an alternative approach to nutritional assessment which could be applicable elsewhere in Africa. The combination of quantitative and qualitative methods was particularly valuable as a means of gaining a wider and deeper understanding of the nature of the nutritional situation.
Young H. Jaspars S. Nutritional assessments, food security and famine. Disasters. 19(1):26-36, 1995 Mar.

Wasting among under fives in Nchelenge, Zambia

The purpose of the study was to compare the use of absolute cut off values of the mid-upper arm circumference (MUAC) with age- and sex-adjusted z scores of the MUAC in the identification of acute undernutrition (wasting) in children up to 60 months of age.

In Nchelenge, northern Zambia, 275 children from the community, selected by a two-stage cluster sampling procedure, and 105 hospitalized children with protein energy malnutrition (PEM) individually matched for age, sex, village and under-five clinic attendance with 104 controls, were clinically and anthropometrically (weight, height, MUAC) examined. zScores for weight for height and MUAC were calculated and PEM was classified according to a modified Wellcome scheme.

For community prevalence rates of wasting in various age groups, MUAC < or = -4 z scores more closely paralleled W/H < or = -2 z scores than MUAC <125 mm. To identify individual children with wasting, MUAC < or = -2 z scores gave a better sensitivity than MUAC <125 mm. In hospitalized PEM children, z scores appeared to offer no advantages over absolute MUAC values in identifying the presence of wasting. Applicability of the MUAC and optimal cut off values may differ according to the setting in which the MUAC is to be applied.
Gernaat HB. Dechering WH. Voorhoeve HW. Absolute values or Z scores of mid-upper arm circumference to identify wasting? Evaluation in a community as well as a clinical sample of under fives from Nchelenge, Zambia. Journal of Tropical Pediatrics. 42(1):27-33, 1996 Feb.

Clinical features of HIV seropositive Zambian subjects

Data was collected from 1595 anti-HIV positive patients out of which 90% of the patients were from the Copperbelt province, and the rest from five out of the eight other provinces of Zambia. One-hundred and one positive HIV patients were less than 2 years of age, 69 were aged 2 to 14 years and 1418 were aged above 15 years.

The male to female ratio was about 1:1 at all ages, except that there was an excess of males below 5 years. Of the four most frequent symptoms or signs, loss of weight or malnutrition was regarded in about 50% of seropositive patients at all ages; generalized lymphadenopathy was seen in at least 35% of all age groups and most frequently at 2-14 (60%); chronic watery diarrhoea was most common at less than 2 years (44%) and least common in older children (17%); chronic chest infections had highest frequency in children 2-14 years (59%) and lowest in adults (32%). Intensive education of children before they are sexually active is the best hope for controlling the epidemic.
Siziya S. Mwendapole R. Fleming AF. Clinical features of HIV seropositive Zambian subjects. African Journal of Medicine & Medical Sciences. 24(2):173-8, 1995 Jun.

HIV type-1 & common paediatric diseases in Zambia

The seroprevalence of HIV-1 and in-patient mortality in children with common pediatric illnesses was studied. Between October 1990 and July 1991 at the Department of Paediatrics and Child Health, University Teaching Hospital (UTH), Lusaka, Zambia, mothers of all pediatric admissions were interviewed and counselled for enrollment of their children into the study.Of a total of 1323 children seen, 1266 children (600 female and 666 male) were enrolled into the study.

Pneumonia (28 per cent), malaria (24 per cent), malnutrition (18 per cent), and diarrhoea (10 per cent) constituted over 80 per cent of the total admission diagnoses. Tuberculosis (5 per cent) was the fifth commonest cause of admission (61 out of 1266 children).

A total of 354 out of the 1266 (28 per cent) children were found to be seropositive for HIV-1 compared to a seroprevalence rate of 9 per cent in children attending accident and emergency for traumatic injuries (P=0.001). High HIV-1 seroprevalence rates were found in children with tuberculosis (69 per cent), malnutrition (41 per cent), pneumonia (28 per cent). and diarrhoea (24 per cent). The overall mortality in hospital among HIV-seropositive children (19 per cent) was significantly higher than those who were HIV-seronegative (9 per cent) (P = < 0.0001).
Chintu C. Luo C. Bhat G. DuPont HL. Mwansa-Salamu P. Kabika M. Zumla A. Impact of the human immunodeficiency virus type-1 on common pediatric illnesses in Zambia. Journal of Tropical Pediatrics. 41(6):348-53, 1995 Dec.

Rotavirus gastro-enteritis in hospitalised children

The clinical and epidemiological aspects of rotavirus diarrhoea were studied in hospitalized children with acute diarrhoea in Lusaka, Zambia. Two hundred and fifty-six (24.0%) of 1069 children admitted to the study were shedding rotavirus.

The rotavirus-positive rate was highest in children less than 1 year of age (37.0%) and it was also high in those less than 6 months old. Rotavirus diarrhoea was seen throughout the year with a higher rotavirus-positive rate in the dry season. In rotavirus-positive diarrhoea patients, more children were dehydrated (82.4%) than in the rotavirus-negative group (56.2%). Rotavirus infection was more common in the children with normal nutritional status (27.6%, 162/588) than in those with malnutrition (19.3%, 93/482). The associated case fatality rate in the rotavirus-positive group was 6.4%, significantly less than in the rotavirus-negative group (OR 0.44, 95% CI 0.24-0.79), and mortality cases were seen only in children less than 2 years old.
Mpabalwani M. Oshitani H. Kasolo F. Mizuta K. Luo N. Matsubayashi N. Bhat G. Suzuki H. Numazaki Y. Rotavirus gastro-enteritis in hospitalized children with acute diarrhoea in Zambia. Annals of Tropical Paediatrics. 15(1):39-43, 1995.

Early cessation of breastfeeding as a major cause of severe malnutrition

One hundred and ten consecutive children under two years of age were admitted because they were affected by severe Protein Energy Malnutrition. They were investigated to know the precipitating cause of their condition.

68 (62%) of them had a history of early weaning from the breast before 2 years, which was followed by a drastic drop of the growth curve. 16 (15%) of them adopted unilateral breast feeding. The study confirms the danger of stopping breast feeding before two years.

This contrasts with other findings from Uganda, Zambia and Botswana which indicate that prolonged breast feeding is associated with higher prevalence of malnutrition in children. Further studies from other countries are necessary and opportune since the basic socio-economic conditions of the population, especially when these are as low as the case in Dodoma Region.
Serventi M. Dal Lago AM. Kimaro DN. Early cessation of breast feeding as a major cause of severe malnutrition in under twos: a hospital based study--Dodoma Region, Tanzania. East African Medical Journal. 72(2):132-4, 1995 Feb.

Population bases surveys of nutritional status

We studied the design effects for population-based surveys that estimated the prevalence of wasting and stunting malnutrition in Malawi, Zambia, Indonesia, and Nepal, and studied the magnitude of different types of malnutrition clustering within villages. Weight, height, and midupper-arm circumference were measured on all children or on systematic samples of children in randomly selected villages.

Design effects ranged from 0.53 for low height-for-age in Zambia to 6.12 for low weight-for-age in Nepal. If all sampled clusters were of size 30, as is often the case for nutrition surveys, design effects would have ranged from 0.44 for low height-for-age in Zambia to 2.59 for low midupper-arm circumference in Zambia.

Malnutrition did cluster within villages. Stunting malnutrition clustered less than did wasting malnutrition. Nutrition surveys using clusters of 30 can sample fewer clusters than currently recommended if basic prevalence and cluster information are available prior to sample selection.
Katz J. Sample-size implications for population-based cluster surveys of nutritional status. American Journal of Clinical Nutrition. 61(1):155-60, 1995 Jan.

Physical growth of under five children in Nchelenge District

This study focuses on the physical growth of children aged 0-60 months in Nchelenge District, northeast Zambia. By means of a two-stage clustered and random sampling method, 193 households were selected. Weight, height, and mid-upper-arm circumference (MUAC) of children 0-60 months were measured. Underweight, stunting, and wasting were defined as weight for age, height for age, and weight for height (W/H), respectively, < or = 2 z scores below the median of the National Center for Health Statistics (NCHS) reference population.

Among 250 children, prevalence rates of 30% underweight, 69.2% stunting, and 4.4% wasting were found, with the highest rates at age 12- < 24 months. Prevalence of stunting, underweight, and wasting in children aged 0- < 6 months and 6- < 12 months suggested that a substantial proportion of infants were premature and/or small for gestational age. The literature suggests that prematurity and intrauterine growth retardation may be quite common in Africa, and this may have important implications for the interpretation of growth data and under nutrition rates. Use of the MUAC < 125 mm as an indicator of wasting resulted in higher estimates of wasting compared to W/H < or = -2 z scores, and seemed unsuitable as a screening test for wasting in this Zambian population.
Gernaat HB. Dechering WH. Voorhoeve HW. Physical growth of children under five years of age in Nchelenge, Zambia: results from a district survey. American Journal of Physical Anthropology. 100(4):473-85, 1996 Aug.


POVERTY IS A VIOLATION OF HUMAN RIGHTS

This article is a call to organisations that work on developing, environmental social justice and human rights issues to work more closely together, arguing that many of the issues these organisations work on are one and the same. It is a call to reflection, debate and action concerning the protection and guarantee of all human rights and of the need to make accountable all actors for their actions that contribute to rights violations.

It should be considered criminal in all jurisdictions - national and international - that at the end of the 20th century, States and other powerful political and economic actors, nationally and internationally, have not taken the decisions and actions necessary to end systematic and historical violations of the wide range of human rights (economic, cultural, civil, social and political) of huge sectors of humanity who struggle, survive and die in varying degrees of endemic poverty and misery.

Since World War II, many more people have been killed by malnutrition, hunger and disease (i.e. systematic violations of human rights) than by the combination of all the wars and all the repressive regimes that have systematically violated political and civil rights.

Seventeen million people in developing countries die each year from such curable infectious and parasitic diseases as diarrhoea, measles, malaria and tuberculosis.' Many times more people struggle and survive in perpetually violatory conditions; even by World Bank estimates, over three billion people survive' on a daily income of US$2, or less.

Adding to the urgency and complexity of properly addressing these issues, a disproportionate percentage of the victims of these violations are women, children indigenous peoples, and other vulnerable sectors of societies. These deaths and sufferings due to imposed conditions of poverty have rarely been analysed or understood as violations of human rights.

12 December 1998 will mark the 50th anniversary of the Universal Declaration of Human Rights (UDHR), the most widely known internal human rights agreement. Government, inter-governmental agencies(such as the United Nation), and national and international non-governmental organisations (NGOs) will carry out activities to mark this date.

50th anniversary should provide a time to celebrate the important advances made to universalise the notion that all humans have rights. Since World War II, tens of thousands of citizen organisations have cropped up at international, national and community levels to popularise the notion that all human have rights, and to carry out education and advocacy work.

The importance of these advances cannot be understated. However, the 50th anniversary is also a time to focus on important questions that governments, other international actors, and the human movement have yet to properly address.

All rights:
Most human rights work to date has focused on certain political and civil rights, to the exclusion of other political and civil rights and a wide range of economic, social and cultural rights. This work has ignored the fact that the UDHR itself enshrines a broad range of economic, social and cultural rights; implicitly, this work has ignored the principle of international law that all human rights are indivisible.

Human rights work has avoided investigating the often times organic relation between poverty (overlapping violations of numerous rights) and repression (a systematic violation of certain political and civil rights). In many countries there has existed/exists a vicious cycle between poverty (violation of numerous rights) and repression(Violations of political and civil rights).

A common scenario is that poor people, and social justice, development and religions workers educate themselves about their rights. They then organise to protest and fight against the rights violations that characterize their lives. Then, the State, often with the support of powerful private sector interests and foreign governments, responds with repression, so as to preserve the undemocratic, unjust status quo.

What has been lacking, in much human rights work, is that while it has investigated and denounced the use of repression (political and civil rights violations), it has not investigated the prior economic, social and cultural rights violations, nor the wide range of actors that contribute to all violations.

All Actors:
Most human rights work has aimed at holding only the state accountable for rights violations (political and civil, for the most part) that occur within its boarders. The actions of other states, and inter-state and private actors often contribute directly and indirectly to a wide range of human and environmental rights violations, whether in their home countries, or in other countries.

Though these other actors often act with impunity, they are rarely held accountable to the people whose rights they may have violated. An example of an inter-state actor contributing to human rights violations in a country would be that of the International Monetary Fund forcefully pressuring the government of a dependent, perhaps indebted, nation to impose political, legal and economic programmes on its people that increase violations of their rights.

An example of a non-state actor violating human rights would be that of a powerful transnational company or bank contributing directly or indirectly through its actions to violations of human rights in a foreign country.

An example of a state actor contributing to human rights violations in another country would be that of one country providing funding, training and/or weaponry to a foreign government (and/or private sector paramilitaries) that is systematically violating the rights of its own people.

Investigating and determining the human rights responsibility of other actors does not negate the responsibility of the state for its contribution to violations, but rather focuses attention on, and proportions responsibility to all other actors that contribute directly and indirectly to violations.

Whether or not the stat was the only actor capable of violating or guaranteeing respect for the rights of its citizens in 1948, it is clearly the case today that other actors impact on human rights as much as, or to a greater man rights as much as, or to a greater degree than, a majority of the existing nation states. While the State will continue to play a central role in how citizens rights are respected, or not, other actors must be held accountable to citizens worldwide whose rights are often negatively affected by their actions.

It is incumbent on the wide range of development, environment, social justice, religious and human rights organisations to understand this, and then bring human rights analysis and actors, holding each actor accountable for its proportion of responsibility in human rights violations.

Challenges - common cause, common language:
The 50th anniversary of the UDHR, thus, provides a focal point for creative activities in he North, South, East, and West, to debate and discuss numerous challenges.

One challenge is for organisation working on human rights, development, environment and social justice issues, at the community, national and international levels, to work more closely together.

An example of how human rights work has been compartmentalised might be that of defending the rain forest' in a country such as Guatemala. Environmental groups' might focus on saving' the forest and the atmosphere, ignoring why it is that poor people of Guatemala are obliged to slash and burn forests just to survive, ignoring how the actions of national and international actors, of national and international actors, controlling the unjust economic/development model, contribute directly to the destruction of the environment. Development groups' might focus on how the reigning development/economic model creates and perpetuates poverty, but will not analysed poverty, as a systematic violation of economic, social and cultural rights, which often leads, organically, to systematic political and civil rights violations.

Human rights groups' might focus exclusively on the State's use the of repression (political and civil rights violations) against activists working to end poverty (violation of numerous rights), ignoring the prior and systematic violation of economic, social and cultural rights (poverty) of the poor sectors, and ignoring how other actors (IMF, WB, other governments etc) contribute directly and indirectly to the violations of economic, cultural and social rights and of political and civil rights.

For these intertwined issues, the international human rights regime provides agreements, law analysis and language that can help overcome the oftentimes false separations between these areas of work.

A cultural and political challenge for all groups working on the interrelated issues is to educate about, and overcome, the accepted truth' that there always has been poverty and there always will be': that poverty is somehow a natural (if not lamentable) phenomenon, as opposed to being the result of economic, legal, political and military decisions taken by humans, states and their many different institutional actors.

And, it is an elemental challenge to make more funding available for groups that are working on the wide range of human rights issues, holding the wide range of actors accountable.

Conclusions:
Human rights work makes it clear that the wide range of violation is neither inevitable nor natural, but arises from deliberate policies, decisions, and actions. In its demand for explanations and accountability, the human rights movement, conceived in the broad sense as set out in this article, exposes the hidden priorities and power structures behind the violations. Thus, addressing all rights, in terms of their economic, political and social context, and holding all actors accountable, constitute critical steps towards challenging the conditions that create and tolerate poverty.

There is much human rights work to be done -at community, national and international levels- to address and reform national and international legal, economic and political systems that remain profoundly unjust.

Now is the time for the wide range of development, social justice, religious, human rights and environmental groups to form working alliances to address these issues. Now is the time to plan creative educational and political activities to mark the date of the 50th anniversary of the UDHR.

Quoted from: Third World Resurgence


SEX AND SEXUALITY

(Commonwealth Regional Health Community Secretariat for East,Central and Southern Africa)

Teenage sexual activities pose serious social, economic, cultural, religious, health and moral problems. Not only do they question the moral fabric of society but they also predispose teenagers to risks of unwanted pregnancies and related consequences, as well as infection with sexually transmitted diseases including the deadly HIV/AIDS.

The study showed that teenage sexual activities were mainly determined by age, early maturity and levels of knowledge on reproductive biology. The levels of sexual knowledge were further related to the sources of and access to relevant information, location of the school and teenagers' sex.

Below were the study highlights:
Teenagers reported significantly high level of knowledge on sexuality; 89 per cent knew of what was involved in sexual intercourse while 90 per cent had correct knowledge of the process leading to pregnancy in a girl. The levels of correct knowledge were higher among older teenagers. Older youth and those from urban schools and higher levels of correct information on sexual intercourse than their younger and rural counterparts.

With regard to sexual practice the study showed that:
Overall, only about one out of every five teenagers were sexually active. Boys reported more sexual experience than girls. Most of the teenager sexual activities were spontaneous. Sixty four per cent of those who engaged in sex had not planned for it.

Family Planning Knowledge and Use:
Knowledge of Family Planning methods was related to availability of correct and adequate information. The correctness of this information was further related to its sources.

Results from the study showed that:
Teenagers had high levels of family planning knowledge. About 70 per cent were familiar with methods of preventing pregnancies. The condom and the pill were the widely known methods. However, when correct knowledge of contraceptive use was summed up and scored against incorrect knowledge, only once out of every for pupils in intervention schools had correct knowledge before intervention. The radio and magazine were the most quoted sources of family planning information (30 per cent), followed by teachers (15 per cent), clinics (11 per cent) and parents (10 per cent). After intervention, magazines and teachers became the most important sources (22 per).

From the study it is clear that use of contraceptive among teenagers depends on several factors. Among the key ones are their availability, correct and adequate knowledge of their reproductive biology. According to the study:

The study indicated that while intervention positively increased the teenagers' levels of family planning knowledge, their level of use declined slightly from about 70 per cent to 64 per cent after intervention. One possible explanation fr this effect could have been the teenagers' increased awareness of reproductive biology which might have reduced the need for contraceptive use among the intervention group.

From: CRHCS Summary of an intervention study on selected aspects of teenage reproductive health - Zimbabwe


QUOTES & MISCELLANEA

Four men were bragging about how smart their dogs are. The first man was an Engineer, the second was an Accountant, the third was a Chemist, and the fourth man was a Government Worker.

To show off, the Engineer called to his dog. "T-Square, do your stuff." T-Square trotted over to a desk, took out some paper and a pen and promptly drew a circle, a square, and a triangle. Everyone agreed that was pretty smart.

The Accountant said his dog could do better, and said, "Slide Rule, do your stuff." Slide Rule went out into the kitchen and returned with a dozen cookies. He divided them into 4 equal piles of 3 cookies each. Everyone agreed that was good.

The Chemist said his dog could do better still, so he called his dog and said, "Measure, do your stuff." Measure got up, walked over to the fridge, took out a quart of milk, got a 10 ounce glass from the cupboard and poured exactly 8 ounces without spilling a drop. Everyone agreed that was great.

The Government Worker called to his dog and said, "Coffee Break, do your stuff!" Coffee Break jumped to his feet, ate the cookies, drank the milk, dumped on the paper, sexually assaulted the other three dogs, claimed he injured his back while doing so, filed a grievance for unsafe working conditions, put in for Workers Compensation and went home on sick leave. Everyone agreed that was absolutely bloody typical!


HARARE (Pan African News Association)
African governments should give priority to women when considering senior positions in the World Health Organisation Regional Office For Africa, regional director Ebrahim Samba said in a statement on Tuesday.

Samba said he was concerned with the low number of women in senior positions in the organisation, prompting him to direct senior staff to identify and develop a pool of qualified women for possible employment in senior positions.

He said the employment of women has been on the agenda of the executive board of the organisation for the past three years. The last African regional committee meeting in Sun City, South Africa, passed a resolution emphasising the need to improve the participation of African women in the work of the organisation.

Employment of women has been Samba's priority since he assumed office in 1995 with two of the five divisional directors and three of the heads of unit in the body being women. Five of the WHO representatives in the African region are also women.

From: HEALTH-L, THE ZAMBIAN ELECTRONIC MAILING LIST ON HEALTH ISSUES


THE CHALLENGE OF REPRODUCTIVE HEALTH IN AFRICA

(MEDICAL LIBRARY ORGANISES SEMINAR ON REPRODUCTIVE HEALTH)

A paper presented to:
The Commonwealth Regional Health Community Secretariat East, Central & Southern Africa - Zambia Dissemination Centre (UNZA Medical Library)
Dr. M.P. Shilalukey Ngoma, FRCP. ( 22nd December 1997 ), Fairview Hotel, Lusaka

INTRODUCTION:


AUTHOR INDEX:

Ahmed, S.19
Ajayi,BB.16
Akanji, AO.22
Akinlade,KS.22
Akoma, MA.16
Akpede, GO.16
Akuhwa,TR.16
Alemu, T 23
Ambe,JP.16
Banduceau,B.14
Belmejdoub,G.14
Bentley,ME.19
Bhat,G28
Brewster, DR.8
Briend,A.11
Bukbuk, DN.16
Caulfield,LE.19
Chintu,C.28
Costello,AM.9
Dal Lago,AM.29
Dechering,WH.30,26
Ducorps,P.14
DuPont,HL.28
Enwonwu,CO.24
Farthing,MJ.17
Ferro-Luzzi,A.20
Fleeming,AF.27
Fuchs, D.17
Gernaat,HB26,30
Golden,MH.11
Graham,SM.8
Gray-Donald K,7,12
Harry,TO.16
Hosp,M.17
James,WP.20
Jaspars,S.10,25
Jupkwo, B.14
Kabika,M.28
Kasolo,M28
Katz,J.29
Kelly,P17
Kensse,J.22
Kimaro,DN.29
Lindtjorn,B23
Loretti,A.12
Luo,C28
Luo,NP.17,28
Mainasara,AS.22
Manary,MJ.8
Mandanda,B.17
Mary, JY.11
Matsubayashi,N.28
Mayandou,H.14
Mizuta,K.28
Mpambalwani,M.28
Mutombo,T.22
Mwansa-Salamu,P.28
Mwendapole,R.27
Ndong,W.14
Needham,D.18
Ngwenya,B.17
Numazaki,Y.28
O'Keefe,SJ.25
Olela,KN.7,13
Oshitani,H.28
Perra,A.9
Pobee,JM.17
Poirier,JM.14
Prudhon,C.11
Rabasa,AL.16
Reed,RD.19
Rothberg,AD.19
Sangare,A22
Scott,M.7,12
Serventi,M.29
Siziya,S.27
Summerbell,C17
Suzuki,H.28
Toole,MJ.15
Tshikuka,JG.7,12
Voorhoeve,HW.26,30
Wachter,R.17
Waldman,RJ.15
Walker,AR.16
Walker,BF.16
Wegerhoff,FO.19
Young,H.10,25
Zumla,A.28

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Last updated October 23, 1998