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Diarrhoea Case Management Research (WHO-DOCS 11)

WHO's Division of Diarrhoeal and Acute Respiratory Disease Control (CDR), among its many activities, supports research into ways of preventing and treating diarrhoeal diseases. The research is coordinated by CDR's Programme for Diarrhoeal Disease Control (CDD). Over the years this research has evaluated a number of new or improved approaches to the control of diarrhoeal diseases. Research findings have been the basis for CDD guidelines for the case management of diarrhoea. As new research results have come to light, CDD has adjusted its case management guidelines accordingly. The following examples related to the nutritional management of patients with diarrhoea show how research has been used to improve CDD's guidelines.

Changes to the CDD treatment chart over time:
CDD's case management guidelines are presented in its diarrhoea management chart. The chart shows health workers how to assess and manage patients who reach a health facility with diarrhoea. The Programme distributed the first such chart in 1980. It proposed that, to prevent dehydration in a child with diarrhoea, the mother should:

Prior to 1980:

1980-1987:
Between 1980 and 1987 research into diarrhoeal diseases produced a number of findings on child nutrition. These confirmed the assumptions underlying the 1980 recommendations, allowing further precision in the advice, and clarified areas of previous uncertainty. The findings showed that:
1987: The diarrhoea management chart was substantially revised in 1987 to reflect the information that had become available since 1980. Consequently the revised chart recommended:
Further studies related to the nutritional management of children with diarrhoea were completed between 1987 and 1990. Among the more significant findings of these studies were the following:
1990:
In view of these findings, CDD again revised the diarrhoea management chart in 1990. This revision incorporated the following recommendations:
If the child has persistent diarrhoea: 1992:
In 1992 results became available from a randomized trial that examined the safety of feeding non-breastfed infants younger than 6 months with their usual milk feeds. The research showed that full-strength milk feeds can be given to non-breastfed infants younger than 6 months during diarrhoea as they provide greater nutrient intake and do not make the symptoms of diarrhoea worse. This finding led CDD to further revise the diarrhoea management chart in 1992. In the latest revision the recommendation is to dilute milk for infants younger than 6 months withacute diarrhoea was removed.

Future changes:
The CDD diarrhoea management chart reflects the fullest and most recent knowledge obtained from reliable research findings. As new findings become available and point to improved ways of managing diarrhoea in young children, however, CDD will revise the diarrhoea management chart further.

For instance, a multicentre trial evaluating guidelines for the management of persistent diarrhoea has recently been completed. Its findings will lead to new recommendations on management of persistent diarrhoea that will be incorporated into future versions of the chart. This close link between research and the establishment of case management guidelines will con-tinue to be an essential element in CDD's work.

For further information, contact:
The Director, Division of Diarrhoeal and Acute Respiratory Disease Control, World Health Organization, 1211 Geneva 27, Switzerland, Tel: +41 22 791-2632, Fax: +41 22 791-4853, E-mail: tullochj@who.ch

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Last updated January 21, 1999