University of Zambia Medical Library
Diarrhoea Case Management Research (WHO-DOCS 11)
WHO's Division of Diarrhoeal and Acute Respiratory Disease Control (CDR), among its many activities, supports research into ways of preventing and treating diarrhoeal diseases. The research is coordinated by CDR's Programme for Diarrhoeal Disease Control (CDD). Over the years this research has evaluated a number of new or improved approaches to the control of diarrhoeal diseases. Research findings have been the basis for CDD guidelines for the case management of diarrhoea. As new research results have come to light, CDD has adjusted its case management guidelines accordingly. The following examples related to the nutritional management of patients with diarrhoea show how research has been used to improve CDD's guidelines.
Changes to the CDD treatment chart over time:
CDD's case management guidelines are presented in its diarrhoea management chart. The chart shows health workers how to assess and manage patients who reach a health facility with diarrhoea. The Programme distributed the first such chart in 1980. It proposed that, to prevent dehydration in a child with diarrhoea, the mother should:
Prior to 1980:
- Give extra breast milk and/or other fluids until the diarrhoea stops.
- Continue normal feeding.
1980-1987:
Between 1980 and 1987 research into diarrhoeal diseases produced a number of
findings on child nutrition. These confirmed the assumptions underlying the
1980 recommendations, allowing further precision in the advice, and
clarified areas of previous uncertainty. The findings showed that:
- Complementary foods offered to children with diarrhoea usually have low energy or nutrient density, so it is important to increase their energy and nutrient density to achieve adequate intake during and after diarrhoea.
- The body continues to absorb animal fats and vegetable oil during diarrhoea.
- promoting improved feeding during an episode of diarrhoea and during convalescence after-wards reduces the negative effects of the episode on a child's nutritional status and does not make the symptoms worse.
- Promoting food safety is important to prevent diarrhoea.
- Continued breastfeeding reduces the severity of the episode of diarrhoea, accelerates recovery and helps prevent further episodes.
1987:
The diarrhoea management chart was substantially revised in 1987 to reflect the information that had become available since 1980. Consequently the revised chart recommended:
- Give freshly prepared foods. Recommended foods are mixes of cereal and
beans, or cereal and meat or fish. Add a few drops of oil.
- Give fresh fruit juices or bananas to provide potassium.
- Cook and mash or grind food well so it will be easier to digest.
- After the diarrhoea stops, give one extra meal each day for a week, or
until the child has regained normal weight.
- Give breast milk or milk feeds prepared with twice the usual amount of water.
Further studies related to the nutritional management of children with diarrhoea were completed between 1987 and 1990. Among the more significant findings of these studies were the following:
- Malnutrition is a significant risk factor for diarrhoea mortality.
- Breast milk represents a high proportion of the nutritional intake of infants with diarrhoea; frequent breastfeeding increases both milk production and the total duration of breastfeeding.
- Local cereal-milk mixtures can provide safe alternatives to milk for older infants and young children with diarrhoea.
- Milk feeds do not need to be diluted for infants 6 months or older.
- Maternal encouragement may be important in improving the food intake of children with diarrhoea.
- It is important to promote the continuation of improved complementary foods after the end of the diarrhoea episode.
- Persistent diarrhoea (lasting 14 days or longer) can represent up to 20% of diarrhoea episodes and have a considerable negative effect on nutritional status.
1990:
In view of these findings, CDD again revised the diarrhoea management chart in 1990. This revision incorporated the following recommendations:
- Give the child plenty of food to prevent malnutrition.
- Continue to breastfeed frequently.
- If the child is not breastfed, give the usual milk. If the child is less than 6 months old and not yet taking solid foods, dilute milk or formula with an equal amount of water for 2 days.
- If the child is 6 months or older, or already taking solid foods, also give cereal or another starchy food mixed, if possible, with pulses, vegetables, and meat or fish. Add 1 or 2 teaspoonfuls of vegetable oil to each serving.
- Encourage the child to eat; offer food at least 6 times a day.
- Give the same foods after diarrhoea stops, and give an extra meal each day for 2 weeks.
If the child has persistent diarrhoea:
- Dilute any animal milk with an equal volume of water or replace it with a fermented milk product such as yoghurt.
- Assure full energy intake by giving 6 meals a day of thick cereal and added oil, mixed with vegetables, pulses, meat or fish.
- Bring the child back in 5 days; if the diarrhoea has not stopped refer to hospital.
1992:
In 1992 results became available from a randomized trial that examined the safety of feeding non-breastfed infants younger than 6 months with their usual milk feeds. The research showed that full-strength milk feeds can be given to non-breastfed infants younger than 6 months during diarrhoea as they provide greater nutrient intake and do not make the symptoms of diarrhoea worse. This finding led CDD to further revise the diarrhoea management chart in 1992. In the latest revision the recommendation is to dilute milk for infants younger than 6 months withacute diarrhoea was removed.
Future changes:
The CDD diarrhoea management chart reflects the fullest and most recent knowledge obtained from reliable research findings. As new findings become available and point to improved ways of managing diarrhoea in young children, however, CDD will revise the diarrhoea management chart further.
For instance, a multicentre trial evaluating guidelines for the management of persistent diarrhoea has recently been completed. Its findings will lead to new recommendations on management of persistent diarrhoea that will be incorporated into future versions of the chart. This close link between research and the establishment of case management guidelines will con-tinue to be an essential element in CDD's work.
For further information, contact:
The Director, Division of Diarrhoeal and Acute Respiratory Disease Control, World Health Organization, 1211 Geneva 27, Switzerland, Tel: +41 22 791-2632, Fax: +41 22 791-4853, E-mail: tullochj@who.ch
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Last updated January 21, 1999